AB680|CD73 inhibitor|CAS 2105904-82-1|DC Chemicals

Cas No.:	2105904-82-1
Chemical Name:	CID 130205852
Synonyms:	J6K8WSV73A;GTPL10707;AB680;[[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid;(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid;CID 130205852 AB 680
SMILES:	ClC1C([H])=C(C2C([H])=NN(C=2N=1)[C@@]1([H])[C@@]([H])([C@@]([H])([C@@]([H])(C([H])([H])OP(C([H])([H])P(=O)(O[H])O[H])(=O)O[H])O1)O[H])O[H])N([H])[C@@]([H])(C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
Formula:	C₂₀H₂₄ClFN₄O₉P₂
M.Wt:	580.824889183044
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

Description:	AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
In Vitro:	AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

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CD73 inhibitor AB-680