AS-1269574|CAS 330981-72-1|DC Chemicals

Cas No.:	330981-72-1
Chemical Name:	AS1269574
Synonyms:	2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol;2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol;AS 1269574;AS-1269574;AS1269574
SMILES:	CC1=CC(=NCCO)N=C(C2=CC=C(C=C2)Br)N1
Formula:	C₁₃H₁₄BrN₃O
M.Wt:	308.173761844635
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays; displays no effect towards the other GPCRs, including the β-adrenergic and GLP-1 receptors; enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions; reduces blood glucose levels, does not affect fed and fasting plasma glucose levels in mice.

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