AZD5718|CAS 2041075-86-7|DC Chemicals

Cas No.:	2041075-86-7
Chemical Name:	AZD5718
Synonyms:	AZD5718\|AZD-5718;AZD 5718
SMILES:	O=C([C@H]1[C@H](C(C2=CC=C(C3=NNC(C)=C3)C=C2)=O)CCCC1)NC4=C(N(N=C4)CCN5)C5=O
Formula:	C₂₄H₂₆N₆O₃
M.Wt:	446.511
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Ericsson H, et al. Clin Transl Sci. 2018 May;11(3):330-338. 2. Pettersen D, et al. J Med Chem. 2019 Mar 14. doi: 10.1021/acs.jmedchem.8b02004.

Description:	AZD5718 (AZD-5718, AZD 5718) is a novel potent 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 of 6.3 nM; exhibits LTB4 inhibition in human whole blood assays with IC50 of 39 nM; reduce the production of pro-inflammatory and vasoactive leukotrienes both in vitro and in vivo.
References:	References 1. Ericsson H, et al. Clin Transl Sci. 2018 May;11(3):330-338. 2. Pettersen D, et al. J Med Chem. 2019 Mar 14. doi: 10.1021/acs.jmedchem.8b02004. View Related Products by Target FLAP

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