ER-464195-01|CAS 859218-37-4|DC Chemicals

Cas No.:	859218-37-4
Chemical Name:	Unii-RV5RD300US
Synonyms:	RV5RD300US;1-Propyl-4-(2-(3,3,5,5-tetramethylcyclohexyl)phenyl)piperazine hydrochloride;Piperazine, 1-propyl-4-(2-(3,3,5,5-tetramethylcyclohexyl)phenyl)-, hydrochloride (1:1);Unii-RV5RD300US
SMILES:	Cl.N1(CCN(CCC)CC1)C1=CC=CC=C1C1CC(C)(C)CC(C)(C)C1
Formula:	C₂₃H₃₉ClN₂
M.Wt:	379.02216553688
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5; dose-dependently and specificly inhibits GST-fused CRT proteins binding to ITGA4 in vitro pull-down assay; inhibits the PMA-induced T cells and the fMLP-stimulated neutrophils bound to VCAM1 (IC50=0.15 μM) and ICAM-1 (IC50=0.19 μM), respectively; suppresses the cell adhesion and the migration of leukocytes, prevents colitis and downregulates the expression of inflammation-related genes in DSS-treated mice, ameliorates the severity of disease in IBD mouse models.

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