HOIPIN-8 |CAS 2519537-70-1|DC Chemicals

Cas No.:	2519537-70-1
Chemical Name:	Benzoic acid
Synonyms:	Sodium (E)-2-(3-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-3-oxoprop-1-enyl)-4-(1-methyl-1H-pyrazol-4-yl)benzoate;G18569;Sodium 2-(3-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-3-oxoprop-1-en-1-yl)-4-(1-methyl-1H-pyrazol-4-yl)benzoate;EX-A7795A;HY-122882;sodium;2-[(E)-3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxoprop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoate;CS-0090162;2519537-70-1;sodium (e)-2-(3-(2,6-difluoro-4-(1h-pyrazol-4-yl)phenyl)-3-oxoprop-1-en-1-yl)-4-(1-methyl-1h-pyrazol-4-yl)benzoate;HOIPIN-8
SMILES:	[Na+].FC1C=C(C=C(C=1C(/C=C/C1=C(C(=O)[O-])C=CC(=C1)C1C=NN(C)C=1)=O)F)C1C=NNC=1
Formula:	C₂₃H₁₅F₂N₄NaO₃
M.Wt:	456.376782655716
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway; suppresses the linear ubiquitination activity by recombinant LUBAC, displays 255-fold increased potency over that of HOIPIN-1 (JTP-0819958, IC50=2.8 uM); also shows 10-fold and 4-fold enhanced inhibitory activities on LUBAC- and TNF-a-induced NF-kB activation respectively, without cytotoxicity; HOIPIN-8 is a powerful tool to explore the physiological functions of LUBAC.

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