ML-191|ML191;|CAS 931695-79-3|DC Chemicals

Cas No.:	931695-79-3
Chemical Name:	3-(1-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-p Henyl-1,3,4-oxadiazol-2(3h)-one
Synonyms:	3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-p henyl-1,3,4-oxadiazol-2(3H)-one;ML-191
SMILES:	CC1C=CC(C2(C(N3CCC(N4N=C(C5C=CC=CC=5)OC4=O)CC3)=O)CC2)=CC=1
Formula:	C₂₄H₂₅N₃O₃
M.Wt:	403.473605871201
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ML-191 is a potent, selective GPR55 antagonist with 160 nM potency for GPR55 and >100-fold selectivity against GPR35, CB1 and CB2; inhibits LPI- mediated ERK1/2 phosphorylation with IC50 of 0.4 uM, inhibits trafficking induced by 10 μM LPI in the β-arrestin trafficking assay with IC50 of 1.08 uM.

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