Fluzoparib|CAS 1358715-18-0|DC Chemicals

Cas No.:	1358715-18-0
Chemical Name:	Fluzoparib (SHR-3162)
Synonyms:	HS10160
SMILES:	FC1C([H])=C([H])C(C([H])([H])C2C3=C([H])C([H])=C([H])C([H])=C3C(N([H])N=2)=O)=C([H])C=1C(N1C([H])([H])C2=NC(C(F)(F)F)=NN2C([H])([H])C1([H])[H])=O
Formula:	C₂₂H₁₆F₄N₆O₂
M.Wt:	472.4
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Fluzoparib (SHR-3162) is a novel, potent and orally available inhibitor of PARP; potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (H)-deficient cells, Fluzoparib preferentially inhibited the proliferation of HR-deficient cells and sensitized both HR-deficient and HR-proficient cells to cytotoxic drugs; demonstrates superior anti-tumor activity in HR-deficient xenografts models, elicited significantly improved anti-tumor responses without extra toxicity in combination with apatinib or with apatinib plus paclitaxel.Ovarian CancerPhase 2 Clinical

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