AMG-510(Sotorasib)|K-RAS(G12C) inhibitor|cas 2296729-00-3

Cas No.:	2296729-00-3
Synonyms:	AMG-510; AMG 510; AMG-510; AMG510;
SMILES:	O=C(N1CCN(C2C3C=C(C(=NC=3N(C3C(C(C)C)=NC=CC=3C)C(=O)N=2)C2C(F)=CC=CC=2O)F)[C@@H](C)C1)C=C
Formula:	C₃₀H₃₀F₂N₆O₃
M.Wt:	560.59
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication:	[1]. Marwan Fakih, et al, Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12Cinhibitor, in advanced solid tumors. Journal of Clinical Oncology. [2]. Karen Rex, et al. Abstract

Description:

AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, thro

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