RS-102895| CAS 300815-41-2

Cas No.:	300815-41-2
Chemical Name:	RS 102895
Synonyms:	RS 102895;1'-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;RS 102895 HYDROCHLORIDE;RS-102895;1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one;RS102895;BDBM442799;CS-3487;Q27088628;1'-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidin]-2-one;BRD-K83063356-003-01-7;CHEBI:93458;NCGC00092306-02;G60944;CID 10000456;SCHEMBL9972649;BCP05302;EN300-20626548;YWB02216;RS102859;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1~{H}-3,1-benzoxazine-4,4'-piperidine]-2-one;HY-18611A;HIDWEYPGMLIQSN-UHFFFAOYSA-N;Z3247512337;TS-10650;BRD-K83063356-003-02-5;R6Q;abaucin;GTPL779;300815-41-2;CHEMBL1593104
SMILES:	O=C1NC2=CC=CC=C2C3(CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)O1
Formula:	C₂₁H₂₁N₂O₂F₃^.HCl
M.Wt:	426.85978
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3. (IC50>17 uM); inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32 nM; significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).

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