AM432 sodium| CAS 1263409-34-2

Cas No.:	1263409-34-2
Chemical Name:	AM432 sodium
SMILES:	[NaH].C(C1C=C(C2=CN=C(OCC)C=C2)C=CC=1C1C=C(CC(=O)O)C=CC=1OC)N(CC)C(C1CC1)=O
Formula:	C₂₉H₃₃N₂NaO₅
M.Wt:	512.57
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Stock N, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1036-40.

Description:

AM 432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2; shows no cross-reactivity against the TP or IP receptors, COX-1 or COX-2 and minimal activity at DP1 receptor; shows excellent potency in a human whole blood eosinophil shape change assay; exhibits efficacy in both a murine model of allergic rhinitis and a cigarette smoke induced inflammatory model of COPD.

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