| Cas No.: | 108303-00-0 |
| Chemical Name: | 3-((S)-2-((2S,3S,4R,6R,8R)-2-ethyl-4,8-dihydroxy-1,5-dioxaspiro[2.5]octan-6-yl)pentanoyl)-2,6-dihydroxy-5-((R)-1-methoxy-2-methylpropyl)benzaldehyde |
| Synonyms: | UCS 15A |
| Formula: | C25H36O9 |
| M.Wt: | 480.554 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | UCS15A is a small moelcule SH3 domain-mediated protein-protein interaction blocking agent that inhibits proline-rich ligand-mediated protein-protein interactions (PLPI); disrupts the interaction of Src-SH3 with Sam68 both in vivo and in vitro, also disrupts the in vivo interactions of Sam68 with other SH3 domain containing proteins such as Grb2 and PLCγ; unable to disrupt the non-SH3-mediated protein-protein interactions of beta-catenin, with E-cadherin and alpha-cateni, and has no effect on the SH2-mediated interaction between Grb2 and activated EGFR; effectively inhibits AMAP1/cortactin binding and breast cancer invasion and metastasis. |

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