GNE-049| CAS 1936421-41-8

Cas No.:	1936421-41-8
Chemical Name:	1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one
Synonyms:	GNE049;GNE 049
SMILES:	FC(F)C1C=C2C(CCCN2C2C3CN(C(=O)C)CCC=3N(C3CCOCC3)N=2)=CC=1C1C=NN(C)C=1
Formula:	C₂₇H₃₂F₂N₆O₂
M.Wt:	510.59
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively; displays 3,850-fold selectivity over BRD4; shows excellent potency (12 nM) in a BRET cellular assay and inhibits the expression of MYC with EC50 of 14 nM in MV-4-11 cells; demonstrates significant dose-dependent inhibition of AR signaling and PC proliferation in vitro and in vivo.

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