NVP-MELK8a hydrochloride| CAS 2096992-20-8

Cas No.:	2096992-20-8
Chemical Name:	MELK-8a hydrochloride
Synonyms:	MELK-8a hydrochloride;MELK-8A HCL;MELK-8a (hydrochloride);1-methyl-4-(4-(4-(3-(piperidin-4-ylmethoxy)pyridin-4-yl)-1H-pyrazol-1-yl)phenyl)piperazine hydrochloride;NVP-MELK8a hydrochloride
SMILES:	Cl.O(C1C=NC=CC=1C1C=NN(C=1)C1C=CC(=CC=1)N1CCN(C)CC1)CC1CCNCC1
Formula:	C₂₅H₃₃ClN₆O
M.Wt:	469.022124052048
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM; exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM); exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.

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