AMD-070 hydrochloride(Mavorixafor)| CAS 880549-30-4

Cas No.:	880549-30-4
Chemical Name:	1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-, hydrochloride (1:1)
Synonyms:	AMD-11070 hydrochloride
SMILES:	[H]Cl.[H]Cl.NCCCCN(C1CCCC2C1=NC=CC=2)CC1NC2C(=CC=CC=2)N=1.[H]Cl
Formula:	C₂₁H₃₀Cl₃N₅
M.Wt:	458.8554
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay; displays no significant activity (IC50>10 uM) for a series of other closely GPCRs (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2); inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 of 2 nM and 26 nM, respectively, with noncytotoxic to cells (>23 uM); exhibits good PK profiles and excellent oral bioavailability; also inhibits CXCR4/SDF-1-mediated events in ALL cancer cells and transplant models.HIV InfectionPhase 3 Clinical

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