BMY 45778| CAS 152575-66-1|DC Chemicals

Cas No.:	152575-66-1
Chemical Name:	Acetic acid,2-[3-(4,5-diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]-
Synonyms:	Acetic acid,2-[3-(4,5-diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]-;2-[3-[4-(4,5-diphenyl-1,3-oxazol-2-yl)-1,3-oxazol-5-yl]phenoxy]acetic acid;BMY 45778;[3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]aceticacid;Tocris-1442;2-[3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid;BMY-045778;BMY45778;[3-(4,5-DIPHENYL[2,4'-BIOXAZOL]-5'-YL)PHENOXY]ACETIC ACID
SMILES:	C1(C2=C(C3C=CC=CC=3)OC(C3=C(C4=CC=CC(OCC(O)=O)=C4)OC=N3)=N2)C=CC=CC=1
Formula:	C₂₆H₁₈N₂O₅
M.Wt:	438.431526660919
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation; activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations; prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets. DyslipidemiaDiscontinued

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