SLx-4090| CAS 913541-47-6

Cas No.:	913541-47-6
Chemical Name:	SLX-4090
Synonyms:	F84YQX13FV;Phenyl 6-(6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)-3,4-dihydroisoquinoline-2(1H)-carboxylate;SB17241;Phenyl 6-(6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)-3,4-dihydroisoquinoline-2(1H)-carboxylate;Phenyl 6-((3-methoxy-2-(4-(trifluoromethyl)phenyl)benzoyl)amino)-3,4-dihydro-1H-isoquinoline-2-carboxylate;2(1H)-Isoquinolinecarboxylic acid, 3,;Phenyl 6-[[3-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxylate;Phenyl 3,4-dihydro-6-[[[6-methoxy-4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-2(1H)-isoquinolinecarboxylate (ACI);SLX-4090
SMILES:	FC(C1C=CC(=CC=1)C1=C(C=CC=C1C(NC1C=CC2CN(C(=O)OC3C=CC=CC=3)CCC=2C=1)=O)OC)(F)F
Formula:	C₃₁H₂₅F₃N₂O₄
M.Wt:	546.536418676376
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM; inhibits apolipoprotein B (IC50=9.6 nM) but not apolipoprotein A1 secretion in Caco-2 cells, reduces postprandial lipids in rats with ED50 of 7mg/kg, decreases the body weight gain and increases HDL-C in ApoE(−/−) mice.DyslipidemiaPhase 2 Clinical

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