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| Cas No.: | 1369170-24-0 |
| Chemical Name: | 5-methylnaphtho[1,2-d]thiazol-2-amine |
| Synonyms: | SKA 111;SKA111 |
| Formula: | C12H10N2S |
| M.Wt: | 214.286 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM; displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels; not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice. |