PF-06446846 hydrochloride| CAS 1632250-50-0

Cas No.:	1632250-50-0
Chemical Name:	N-(3-Chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide
Synonyms:	(R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide;BDBM200332;US9227956, 16;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide;N-(3-Chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide;PF-06446846 hydrochloride;MS-28694;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride;EX-A7051A;PF-06446846 HCl;HY-120088A;CS-0085754;N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride;PF846;PF-06446846 (hydrochloride);BP166582;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide;hydrochloride;1632250-50-0;PF 06446846 hydrochloride;G16409;AKOS040742400;(R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide hydrochloride
SMILES:	ClC1C([H])=C([H])C([H])=NC=1N(C(C1C([H])=C([H])C(=C([H])C=1[H])N1C2=C(C([H])=C([H])C([H])=N2)N=N1)=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
Formula:	C₂₂H₂₀ClN₇O
M.Wt:	433.8935
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells; shows no general effect on the secreted and intracellular proteome; induces the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel; reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.

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