ML-162| CAS 1035072-16-2|DC Chemicals

Cas No.:	1035072-16-2
Chemical Name:	ML162
Synonyms:	SMR000206941;2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide;MLS000583955;ML162;2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide;BRD5421;MLS002703080;MLS002588779;cid_3689413;BDBM66431;AOB1514;HMS3874J03;HMS2544O20;Q27163480;s4452;BRD-A36275421-001-14-5;2-[2-chloro-N-(3-chloro-4-methoxyphenyl)acetamido]-N-(2-phenylethyl)-2-(thiophen-2-yl)acetamide;F86422;alpha-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide;2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-N-(2-phenylethyl)-2-thiophen-2-yl-ethanamide;BRD-A36275421-001-04-6;GLXC-02623;BRD-A36275421-001-13-7;1035072-16-2;2-(3-chloro-N-(2-chloroacetyl)-4-methoxy-anilino)-N-phenethyl-2-(2-thienyl)acetamide;CHEMBL1499544;2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide;ML-162;SR-01000705401-2;CS-0017910;AS-16657;BRD-A36275421-001-09-5;SCHEMBL15428380;AC-36618;2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide;SR-01000705401;CHEBI:91657;DPI7;BRD-5421;AKOS024440074;HY-100002;BRD-A36275421-001-15-2;ML-162?;BRD-A36275421-001-06-1;GTPL12800;BRD-A36275421-001-11-1;EX-A4946
SMILES:	ClC([H])([H])C(N(C1C([H])=C([H])C(=C(C=1[H])Cl)OC([H])([H])[H])C([H])(C(N([H])C([H])([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)C1=C([H])C([H])=C([H])S1)=O
Formula:	C₂₃H₂₂Cl₂N₂O₃S
M.Wt:	477.4034
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.

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