FB23-2(FTO Demethylase inhibitor FB23-2)| CAS 2243736-45-8

Cas No.:	2243736-45-8
Chemical Name:	2-((2,6-dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide
SMILES:	CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)NO)Cl
Formula:	C₁₈H₁₅Cl₂N₃O₃
M.Wt:	392.236
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM[1].
Target:	IC50: 2.6 μM (FTO)[1]
In Vivo:	FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice[1].
In Vitro:	FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells[1]. FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM[1].
References:	[1]. Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.

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