LM22A-4| CAS 37988-18-4

Cas No.:	37988-18-4
Chemical Name:	1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-
Synonyms:	LM 22A4
SMILES:	OCCNC(C1C=C(C(NCCO)=O)C=C(C(NCCO)=O)C=1)=O
Formula:	C₁₅H₂₁N₃O₆
M.Wt:	339.3438
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not p75; activates TrkB signaling and prevents neuronal degeneration in rodents; rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.

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