SKF 82958| CAS 80751-65-1|DC Chemicals

Cas No.:	80751-65-1
Chemical Name:	1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-
Synonyms:	1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-;(+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE;(+/-)-CHLORO-APB HYDROBROMIDE;Chloro-APB hydrobromide;(±)-SKF 82958;1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl);6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol;6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;Chloro-APB;Cl-apb;(±)-SKF-82958 hydrobromide;(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide;6-Chloro-N-allyl-SKF-38393 hydrobromide
SMILES:	Br.C=CCN1CC(C2=CC=CC=C2)C3C(CC1)=C(Cl)C(O)=C(O)C=3
Formula:	C₁₉H₂₀NO₂Cl^.HBr
M.Wt:	410.73254
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	SKF 82958 is a D1/D5 receptor full agonist.
Target:	D1/D5 receptor
In Vivo:	Quantitative in situ hybridization was used to examine the contribution of muscarinic receptors to the transynaptic regulation of striatal gene expression induced by D1receptor activation. The acute injection of the full D1 agonist, SKF-82958, would induce PPD, SP and PPE mRNA expression in the intact rat striatum.
In Vitro:	Neuropeptide and immediate early gene expression in striatonigral neurons of the normosensitive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and preprodynorphin (PPD) and substance P (SP) gene expression in medium spiny neurons in the dorsal, and especially, in the ventral striatum.
References:	[1]. Wang JQ, et al. The Full D1 Dopamine Receptor Agonist SKF-82958 Induces Neuropeptide mRNA in the Normosensitive Striatum of Rats: Regulation of D1/D2 Interactions by Muscarinic Receptors.J Pharmacol Exp Ther. 1997 May;281(2):972-82.

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