CP-339818 hydrochloride| CAS 478341-55-8|DC Chemicals

Cas No.:	478341-55-8
Chemical Name:	CP 339818 hydrochloride
Synonyms:	CP 339818 hydrochloride
SMILES:	Cl.CCCCC/N=C1/C=CN(CC2=CC=CC=C2)C2=CC=CC=C/12
Formula:	C₂₁H₂₅ClN₂
M.Wt:	340.889604330063
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM; displays selectivity over Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2, with only exception Kv1.4 (IC50=300 nM), also has no effect on T cell channels (I(CRAC) and intermediate-conductance K(Ca)); inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel; suppresses human T cell activation.

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