VU0134992| CAS 755002-90-5|DC Chemicals

Cas No.:	755002-90-5
Chemical Name:	2-(2-Bromo-4-iso-propylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Synonyms:	VU 0134992
SMILES:	O=C(NC1CC(C)(C)NC(C)(C)C1)COC2=CC=C(C(C)C)C=C2Br
Formula:	C₂₀H₃₁BrN₂O₂
M.Wt:	411.384
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Kharade SV, et al. Mol Pharmacol. 2018 Jun 12. pii: mol.118.112359.

Description:	VU0134992 is a selective inward rectifier potassium (Kir) channel Kir4.1 blocker with an IC50 of 0.97 µM[1].
Target:	IC50: 0.97 µM (Kir4.1)[1]
In Vitro:	VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2, is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1, and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2[1].
References:	[1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.

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