| Cas No.: | 2176486-23-8 |
| Chemical Name: | (3-(((4-(4-((7-oxo-7H-furo[3,2-g]chromen-4-yl)oxy)butoxy)phenoxy)carbonyl)amino)propyl)triphenylphosphonium iodide |
| Formula: | C43H39InO7P |
| M.Wt: | 839.663 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM; does not inhibit Kv1.1 and Kv1.5, two related members of the Kv family; kills 98% of ex vivo primary chronic B-lymphocytic leukemia tumor cells while sparing healthy B cells; significantly reduces tumor size in orthotopic mouse models of melanoma and pancreatic ductal adenocarcinoma. |

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