BTYNB| CAS 304456-62-0

Cas No.:	304456-62-0
Chemical Name:	BTYNB
Synonyms:	BTYNB
SMILES:	C1(/N=C/C2=CC=C(S2)Br)C=CC=CC=1C(=O)N
Formula:	C₁₂H₉BrN₂Os
M.Wt:	309.18
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM; has no effect on binding of PR to flPRE; destabilizes c-Myc mRNA, downregulates β-TrCP1 mRNA and reduces activation of NF-κB; also decreases oncogenic translation regulator eEF2 mRNA levels in cancer cells; potently inhibits proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.

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