Netoglitazone(MCC-555)| CAS 161600-01-7|DC Chemicals

Cas No.:	161600-01-7
Chemical Name:	5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione
Synonyms:	5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione,5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-;5-[[6-[(2-fluorophenyl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione;Mcc-555;MIsaglitazone;Netoglitazone;UNII-QOV2JZ647A;5-[[6-[(2-Fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione;Isaglitazone;RWJ 241947;MCC-555;5-[[6-[(2-FLUOROPHENYL)METHOXY]-2-NAPHTHALENYL]METHYL]-2,4-THIAZOLIDINEDIONE;NETOGLITAZONE,2,4-THIAZOLIDINEDIONE, 5-[[6-[(2-FLUOROPHENYL)METHOXY]-2-NAPHTHALENYL]METHYL]-
SMILES:	FC1C=CC=CC=1COC1=CC=C2C(C=CC(CC3SC(=O)NC3=O)=C2)=C1
Formula:	C₂₁H₁₆FNO₃S
M.Wt:	381.42004776001
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653; profoundly suppresses growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue.DiabetesPhase 2 Discontinued

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Netoglitazone(MCC 555)