Rheb inhibitor NR1| CAS 2216763-38-9|DC Chemicals

Cas No.:	2216763-38-9
Chemical Name:	Rheb inhibitor NR1
Synonyms:	Rheb inhibitor NR1;4-Bromo-6-((3,4-dichlorophenyl)thio)-1-(4-(dimethylcarbamoyl)benzyl)-1H-indole-2-carboxylic acid;4-bromo-6-[(3,4-dichlorophenyl)sulfanyl]-1-{[4-(dimethylcarbamoyl)phenyl]methyl}-1H-indole-2-carboxylic acid;NR1;BrC1=C2C=C(N(C2=CC(=C1)SC1=CC(=C(C=C1)Cl)Cl)CC1=CC=C(C=C1)C(N(C)C)=O)C(=O)O;E7V
SMILES:	BrC1=CC(=CC2=C1C=C(C(=O)O)N2CC1C=CC(C(N(C)C)=O)=CC=1)SC1C=CC(=C(C=1)Cl)Cl
Formula:	C₂₅H₁₉BrCl₂N₂O₃S
M.Wt:	578.304962396622
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK; in contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment, potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo.

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