BCX-1470 methanesulfonate| CAS 217099-44-0

Cas No.:	217099-44-0
Chemical Name:	BCX 1470 methanesulfonate
Synonyms:	2-Thiophenecarboxylic acid 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester methanesulfonate (1:1);2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester 2-Thiophenecarboxylic acid methanesulfonate;BCX 1470;BCX 1470 METHANESULFONATE;BCX-1470;BCX 1470 (methanesulfonate);BCX 1470 methanesulfonate;CS-0314;AKOS030526720;F83644;BCX 1470(methanesulfonate);BCX1470methanesulfonate;HMS3748M19;FT-0767761;(2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate;methanesulfonic acid;CHEMBL2203422;MS-26738;HY-50875;217099-44-0
SMILES:	N=C(C1=CC2=CC=C(OC(C3=CC=CS3)=O)C=C2S1)N.O=S(O)(C)=O
Formula:	C₁₄H₁₀N₂O₂S₂^.CH₄O₃S
M.Wt:	398.47706
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM); displays 3.4-fold and 200-fold bette than that of trypsin, respectively; inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively); blocks the reverse passive Arthus (RPA) reaction in rats.ThrombosisPhase 1 Discontinued

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