YM-155 hydrochloride| CAS 355406-09-6|DC Chmeicals

Cas No.:	355406-09-6
Chemical Name:	1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(2-pyrazinylmethyl)-, chloride (1:1)
Synonyms:	YM155 hydrochloride;YM 155 hydrochloride
SMILES:	[Cl-].CC1=[N+](CC2=NC=CN=C2)C2C(C3C(C(=O)C=2N1CCOC)=CC=CC=3)=O
Formula:	C₂₀H₁₉ClN₄O₃
M.Wt:	398.8429
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity (>30 uM); suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins; induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).Blood CancerPhase 1 Discontinued

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