CYT387 sulfate salt| CAS 1056636-06-6

Cas No.:	1056636-06-6
Chemical Name:	Momelotinib sulfate
Synonyms:	Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, sulfate (1:2);CYT387 sulfate salt;N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide, sulfuric acid;CS-0765;CYT 387 sulfate;CYT-387 sulfate;CYT387,H2SO4salt;momelotinib sulfate;N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide sulfate (1:2);CYT387 2H2SO4 salt;CYT 387 sulfate (1:2);CYT387 (sulfate salt);Momelotinib sulfate
SMILES:	O=C(NCC#N)C(C=C1)=CC=C1C2=NC(NC(C=C3)=CC=C3N4CCOCC4)=NC=C2.O=S(O)(O)=O.O=S(O)(O)=O
Formula:	C₂₃H₂₂N₆O₂^.₂[H₂O₄S]
M.Wt:	610.61674
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM; shows significantly less activity against other kinases, including JAK3 (IC50=155 nM); inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM; inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM). Bone CancerPhase 3 Clinical

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