TH-287 hydrochloride| CAS 1638211-05-8

Cas No.:	1638211-05-8
Chemical Name:	TH287 (hydrochloride)
Synonyms:	TH287 (hydrochloride);TH-287 hydrochloride;TH 287 hydrochloride;TH287 hydrochloride, >=98% (HPLC);6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride;TH287 hydrochloride
SMILES:	ClC1C(=C([H])C([H])=C([H])C=1C1=C([H])C(=NC(N([H])[H])=N1)N([H])C([H])([H])[H])Cl.Cl[H]
Formula:	C₁₁H₁₁Cl₃N₄
M.Wt:	305.5908
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

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