GLS1 Inhibitor| cas 1832646-52-2|DC Chemicals

Cas No.:	1832646-52-2
Chemical Name:	αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-benzeneacetamide
Synonyms:	αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-benzeneacetamide
SMILES:	CO[C@H](C(NC1=NN=C(N[C@@H]2CCN(C3=CC=CN=N3)C2)S1)=O)C4=CC=CC=C4
Formula:	C₁₉H₂₁N₇O₂S
M.Wt:	411.5
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GLS1 inhibitor is an inhibitor of glutaminase 1
In Vitro:	GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM).1 It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.

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