NSC-92828|cas 13728-56-8|DC Chemicals

Cas No.:	13728-56-8
Chemical Name:	3-Phenanthrenebutanoicacid
SMILES:	OC(=O)CCCC1=CC2C3C(=CC=CC=3)C=CC=2C=C1
Formula:	C₁₈H₁₆O₂
M.Wt:	264.31844
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	NSC-92828 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a Kd of 6.7 μM[1].
Target:	HIV-1 Nef:6.7 μM (Kd)
In Vitro:	HIV-1 Nef-IN-1 (Compound D11; 20 μM) inhibits cell viability of COS7 cells, and the cell inhibition rate is 63.2%[1].
References:	[1]. Stéphane Betzi, et al. Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19256-61.

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