DOTATATE acetate|CAS 177943-89-4|DC Chemicals

Cas No.:	177943-89-4
Chemical Name:	DOTA-TATE acetate
Synonyms:	{D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
SMILES:	[{D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7) (acetate salt)]
Formula:	C₆₇H₉₄N₁₄O₂₁S₂
M.Wt:	1495.69
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

Description:	DOTATATE acetate, a DOTA-conjugated peptide, and can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[1][2][3][4].
In Vivo:	177Lu-DOTATATE shows excellent antitumor effects in rats[1].
References:	[1]. Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S. [2]. Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10. [3]. Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20. [4]. Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82.

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