FEN1-IN-4|CAS 1995893-58-7|DC Chemicals

Cas No.:	1995893-58-7
Chemical Name:	1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione
Synonyms:	FEN1 Inhibitor C2;FEN1-IN-4;1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione
SMILES:	ON1C(=O)N(CC2CC2)C3C(=CC=CC=3)C1=O
Formula:	C₁₂H₁₂N₂O₃
M.Wt:	232.2353
Purity:	>98%
Sotrage:	Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month

Description:	FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1].
Target:	hFEN1[1]
In Vitro:	FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1].
References:	[1]. Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12(10):815-21.

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