FtsZ inhibitor C109|Compound 10126109

Cas No.:
Chemical Name:	methyl 2-((4-nitrobenzo[c][1,2,5]thiadiazol-5-yl)thio)acetate
Synonyms:	FtsZ inhibitor C109\|Compound 10126109
Formula:	C₉H₇N₃O₄S₂
M.Wt:	285.292
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM; inhibits both the GTPase and polymerization activities of purified B. cenocepacia FtsZ, prevents divisome formation by altering the localization of the essential cell division protein FtsZ; displayes antibacterial activity against Gram-positive and Gram-negative cystic fibrosis pathogens, including Mycobacterium abscessus, C109 effectively cleared B. cenocepacia infection in the Caenorhabditis elegans model and exhibited additive interactions with clinically relevant antibiotics.

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