GW-506033X(PKR Inhibitor C16)CAS 608512-97-6|DC Chemicals

Cas No.:	608512-97-6
Chemical Name:	6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Synonyms:	GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor.
SMILES:	O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4
Formula:	C₁₃H₈N₄Os
M.Wt:	268.294
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GW-506033X(PKR Inhibitor C16) is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures[1].
References:	[1]. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.

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