HS-10|HS10|HSP90 Inhibitor

Cas No.:
Chemical Name:	HS-10
Synonyms:	HS10;HS 10
SMILES:	CC1=NN(C2=CC(N[C@H]3CC[C@H](O)CC3)=C(C(N)=O)C=C2)C2=C1C(=O)CC(C)(C)C2
Formula:	C₂₃H₃₀O₃N₄
M.Wt:	410.52
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C. HS-10 alone also induced degradation of HER2 and Akt, as well as increased Hsp70 protein levels as expected, due to the negative regulatory role that Hsp90 has on heat shock transcription factor 1.

Cat. No.	Product name	Field of application
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DC6307	XL888	XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
DC8299	VER155008	VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines.
DC9948	SNX-5422(PF04929113)	PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM).
DC4118	NVP-BEP800	NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM.
DC9994	ML-346	ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
DC9963	Kribb11	KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM).
DC8247	KNK437	KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
DC10852	KBU2046	KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs.