IEM 1754 DihydrobroMide|cas 162831-31-4

Cas No.:	162831-31-4
Synonyms:	IEM1754 dihydrobromide;IEM1754 2 HBr; AOB5933;
Formula:	C₁₆H₃₂Br₂N₂
M.Wt:	412.25
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits.IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization.

Cat. No.	Product name	Field of application
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