JT010|CAS 917562-33-5|DC Chemicals

Cas No.:	917562-33-5
Chemical Name:	2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide
Synonyms:	JT010; JT-010; JT 010.
SMILES:	O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
Formula:	C₁₆H₁₉ClN₂O₃S
M.Wt:	354.849
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.
Publication:	[1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.

Description:	JT010 is a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT010 opens the TRPA1 channel by covalently and site-selectively binding to Cys621 (EC50 = 0.65 nM). The results suggest that a single modification of Cys621 is sufficient to open the TRPA1 channel. The TRPA1-selective probe described herein might be useful for further mechanistic studies of TRPA1 activation.
Target:	EC50: 0.65 nM (TRPA1)[1]
References:	[1]. Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.

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