KL-1333|CAS 1800405-30-4|DC Chemicals

Cas No.:	1800405-30-4
Chemical Name:	2-(1-Methylethyl)-3H-naphth(1,2-d)imidazole-4,5-dione
Synonyms:	KL-1333; KL 1333; KL1333;
SMILES:	O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O
Formula:	C₁₄H₁₂N₂O₂
M.Wt:	240.262
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552.

Description:	NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1].
Target:	NQO1[1]
References:	[1]. Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552.

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KL-1333(NQO1 activator 1)