LMT-28|cas 1239600-18-0|DC Chemicals

Cas No.:	1239600-18-0
Chemical Name:	(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone
Synonyms:	(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone;BDBM50145193;(4S)-3-[(2S,3S)-3-hydroxy-2-methyl-4-methylidenenonanoyl]-4-propan-2-yl-1,3-oxazolidin-2-one
SMILES:	O1C(N(C([C@@]([H])(C([H])([H])[H])[C@@]([H])(C(=C([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])O[H])=O)[C@]([H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=O
Formula:	C₁₇H₂₉NO₄
M.Wt:	311.4165
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130; does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells; binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex; inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM; inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice.

References:

References 1. Hong SS, et al. J Immunol. 2015 Jul 1;195(1):237-45. 2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z. View Related Products by Target Interleukin Receptor

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