LY 333328；Oritavancin (phosphate)|cas 192564-14-0

Cas No.:	192564-14-0
Chemical Name:	Oritavancin diphosphate
Synonyms:	oritavancin bisphosphate;LY333328 diphosphate;Oritavancin (phosphate);Oritavancin Diphosphate;Oritavancin (diphosphate);Orbactiv;LY 333328 diphosphate;oritavancin phosphate;VL1P93MKZN;Oritavancin diphosphate [USAN];Oritavancin diphosphate (USAN);Orbactiv (TN);LY 33332;Oritavancin diphosphate
SMILES:	ClC1=C2C([H])=C([H])C(=C1[H])[C@]([H])([C@@]1([H])C(N([H])[C@]([H])(C(=O)O[H])C3C([H])=C(C([H])=C(C=3C3=C(C([H])=C([H])C(=C3[H])[C@]([H])(C(N1[H])=O)N([H])C([C@@]1([H])C3=C([H])C(=C(C(=C3[H])O2)O[C@@]2([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])O[H])O2)O[H])O[H])O[C@@]2([H])C([H])([H])[C@@](C([H])([H])[H])([C@]([H])([C@]([H])(C([H])([H])[H])O2)O[H])N([H])C([H])([H])C2C([H])=C([H])C(C3C([H])=C([H])C(=C([H])C=3[H])Cl)=C([H])C=2[H])OC2C([H])=C([H])C([C@]([H])([C@]([H])(C(N([H])[C@@]([H])(C([H])([H])C(N([H])[H])=O)C(N1[H])=O)=O)N([H])C([C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])[H])=O)O[H])=C([H])C=2Cl)=O)O[H])O[H])O[H])=O)O[C@@]1([H])C([H])([H])[C@@](C([H])([H])[H])([C@]([H])([C@]([H])(C([H])([H])[H])O1)O[H])N([H])[H].P(=O)(O[H])(O[H])O[H].P(=O)(O[H])(O[H])O[H]
Formula:	C₈₆H₁₀₃Cl₃N₁₀O₃₄P₂
M.Wt:	1989.09
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Oritavancin is a semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria.It inhibits transglycosylation and transpeptidation in the bacterial cell wall to disrupt membrane integrity.Oritavancin inhibits the growth of clinical isolates from skin and soft-tissue infections, including methicillin-resistant and -susceptible S. aureus (MRSA, MSSA), vancomycin-resistant and -susceptible E. faecium (VREF, VSRF), as well as other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L).Oritavancin inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for a single dose).It improves survival in a mouse inhalation model of B. anthracis Ames anthrax when administered prophylactically pre- and postexposure and when administered post symptom development.Formulations containing oritavancin have been used to treat bacterial skin infections.

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