MK-2894|cas 1006036-87-8|DC Chemicals

Cas No.:	1006036-87-8
Synonyms:	MK 2894;MK2894
SMILES:	O=C(O)C1=CC=C(C2(NC(C3=C(C)SC(C)=C3CC4=CC=C(C(F)(F)F)C=C4)=O)CC2)C=C1
Formula:	C₂₅H₂₂F₃NO₃S
M.Wt:	473.5073
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MK-2894 is a highly potent and selective second generation EP4 antagonist. MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

Cat. No.	Product name	Field of application
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DC47374	Aligeron	Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
DC47373	CAY10580	CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
DC47183	Aganepag isopropyl	Aganepag isopropyl (AGN-210961) is an EP2 agonist.
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DC47127	Pexopiprant	Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma.
DC47089	Treprostinil palmitil	Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.
DC46853	BGC-20-1531 free base	BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache.
DC46564	Bimatoprost D5	Bimatoprost D5 (AGN 192024 D5) is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect.
DC45799	TCS 2510	TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.