MMP-1 Fluorogenic Substrate I|cas 135662-04-3

Cas No.:	135662-04-3
Chemical Name:	Dnp-PLALWAR pound>>Matrix Metalloproteinase-1 Fluorogenic Substrate I pound>>MMP-1 Fluorogenic Substrate I
Synonyms:	Dnp-PLALWAR pound>>Matrix Metalloproteinase-1 Fluorogenic Substrate I pound>>MMP-1 Fluorogenic Substrate I
SMILES:	O=C([C@@H]1CCCN1C1C=CC(=CC=1[N+](=O)[O-])[N+](=O)[O-])N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(=O)O)CCC/N=C(\N)/N)=O)=O)CC1=CNC2C=CC=CC1=2)=O)CC(C)C)=O)=O)CC(C)C
Formula:	C₄₆H₆₅N₁₃O₁₂
M.Wt:	992.088209867477
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	MMP-1 Fluorogenic Substrate I(Dnp-PLALWAR) is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8.The activity of MMP-1 and MMP-8 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
In Vitro:	MMP-1 Fluorogenic Substrate I(Dnp-PLALWAR) is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8.The activity of MMP-1 and MMP-8 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.

Cat. No.	Product name	Field of application
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DC70174	ADAM17 inhibitor SN-4	ADAM17 inhibitor SN-4 is a newly identified, highly specific inhibitor of ADAM17 (A disintegrin and metalloproteinase 17), demonstrating potent activity in blocking TNF-α cleavage in cellular assays with an IC50 value of 3.22 µM. This compound exhibits slightly greater efficacy compared to marimastat, a well-established ADAM17 inhibitor. In vitro studies reveal that SN-4 effectively suppresses ADAM17-mediated cleavage of tumor necrosis factor α (TNF-α) and CD44, while showing no significant impact on ADAM10 activity. Additionally, SN-4 has been shown to inhibit cellular invasion, highlighting its potential as a targeted therapeutic agent for modulating ADAM17-related pathways.
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DC28161	ARP-100	ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).
DC11355	MMP-3 Inhibitor	MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
DC11338	MMP-2/MMP-7 Fluorogenic Substrate Control	Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7.
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