MPTP (hydrochloride)|cas 23007-85-4|DC Chemicals

Cas No.:	23007-85-4
Chemical Name:	MPTP
Synonyms:	MPTP
SMILES:	CN1CCC(C2=CC=CC=C2)=CC1.Cl
Formula:	C₁₂H₁₆ClN
M.Wt:	209.7151
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease.
In Vivo:	The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].
In Vitro:	Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].

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