MitoBloCK-10 |CAS 394694-98-5|DC Chemicals

Cas No.:	394694-98-5
Chemical Name:	MitoBloCK-10
Synonyms:	3-Fluoro-N-[(Z)-(5-nitrothiophen-2-yl)methylideneamino]benzamide;MitoBloCK-10
SMILES:	S1C(=CC=C1/C=N\NC(C1C=CC=C(C=1)F)=O)[N+](=O)[O-]
Formula:	C₁₂H₈FN₃O₃S
M.Wt:	293.273624420166
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway; targets Tim44 and mutations in the α4 helix of the C-terminal domain of Tim44 confer resistence to MitoBloCK-10 (MB-10); MitoBloCK-10 (MB-10) inhibits Tim44 binding to the precursor and to Hsp70, but not other component of the PAM complex; inhibits Hela cell viability with IC50 of 17.2 uM in MTT assays, impairs cardiac development and induces apoptosis in zebrafish.

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