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Nicotinamide riboside

  Cat. No.:  DC32224   Featured
Chemical Structure
1341-23-7
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More than 5000 active chemicals with high quality for research!
Field of application
Nicotinamide riboside, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NR blocks degeneration of surgically severed dorsal root ganglion neurons ex vivo and protects against noise-induced hearing loss in living mice. Nicotinamide riboside prevents muscle, neural and melanocyte stem cell senescence. Increased muscular regeneration in mice has been observed after treatment with nicotinamide riboside, leading to speculation that it might improve regeneration of organs such as the liver, kidney, and heart. Nicotinamide riboside also lowers blood glucose and fatty liver in prediabetic and type 2 diabetic models while preventing the development of diabetic peripheral neuropathy. Note: Nicotinamide Riboside chloride is a α/β mixture
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 1341-23-7
Chemical Name: Nicotinamide riboside
Synonyms: Nicotinamide ribose;N-ribosylnicotinamid;3-(Aminocarbonyl)-1beta-D-ribofuranosylpyridinium;1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide;Nicotinamide riboside-oxidized form;NRH-oxidized form;Nicotinamide ribonucleoside;NICOTINAMIDE RIBOSIDE;Nicotiamide Riboside;N-ribosylnicotinamide;NR(Nicotinamide Riboside);nicotinamide-beta-riboside;ribosylnicotinamide;1-(beta-D-Ribofuranosyl)nicotinamide;0I8H2M0L7N;Pyridinium, 3-(aminocarbonyl)-1-beta-D-ribofuranosyl-;3-carbamoyl-1-beta-D-ribofuranosylpyridinium;3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium;SRT647;SRT 647;N-ribosyl-nicotinamide;beta-nicotinamide D-ribosi;Nicotinamide riboside chloride;Q3334152;C03150;DTXSID501010039;DB14933;1-b-D-ribosyl-3-Pyridinecarboxamide;nicotinamide riboside;3-(aminocarbonyl)-1-beta-delta-ribofuranosyl-Pyridinium;1-(beta-D ribofuranosyl)nicotinamide;AM84366;CHEMBL438497;UNII-0I8H2M0L7N;1-beta-delta-ribosyl-3-Pyridinecarboxamide;BETA-nicotinamide ribose;Beta-Nicotinamide Riboside;Niagen;SRT-647;SCHEMBL938611;NICOTINAMIDE RIBOSIDE [WHO-DD];3-(aminocarbonyl)-1-beta-d-ribofuranosylpyridinium;Pyridinium, 3-(aminocarbonyl)-1-.beta.-D-ribofuranosyl-;CS-0080934;HY-123033;3-(aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium;nicotinamide ribonucleoside;1341-23-7;CHEBI:15927;TruNiagen;AKOS040740858;1-beta-D-ribosyl-3-Pyridinecarboxamide;nicotinamide ribose;3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1$l^{5}-pyridin-1-ylium;beta-nicotinamide D-riboside;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;Nicotinamide Ribose;Nicotinamide Riboside 99%;3-(AMinocarbonyl)-1beta-D-ribofuranosylpyridiniuM
SMILES: O1[C@]([H])(C([H])([H])O[H])[C@]([H])([C@]([H])([C@]1([H])[N+]1=C([H])C([H])=C([H])C(C(N([H])[H])=O)=C1[H])O[H])O[H]
Formula: C11H15N2O5
M.Wt: 255.2472
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1].
Target: SIRT1 SIRT3
In Vivo: Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner.
In Vitro: Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2.
References: [1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.
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