RCGD423|CAS 108237-91-8| gp130 modulator|DC Chemicals

Cas No.:	108237-91-8
Synonyms:	RCGD423;RCGD-423;RCGD 423
SMILES:	BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2
Formula:	C₁₅H₁₁BrN₂S
M.Wt:	331.23
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.

Description:	RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
Target:	gp130[1]
In Vivo:	RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1].
In Vitro:	RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1].
References:	[1]. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.

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